Since the magnitude of the effect derived from observational studies can be misleading, we opted for a sequential trial design with two-sided alternatives20; the trial design called for analyses to be performed after inclusion of the first 50 and 100 patients, and then after inclusion of each additional 100 patients, and allowed for the discontinuation of the trial according to the following predefined boundaries: superiority of norepinephrine over dopamine, superiority of dopamine over norepinephrine, or no difference between the two. An independent statistician who is also a physician monitored the efficacy analyses and the adverse events; on October 6, 2007, after analysis of the outcome in the first 1600 patients showed that one of the three predefined boundaries had been crossed, the statistician advised that the trial be stopped.
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Important Update! – I have been receiving a few emails/comments on players tracking their jump during the course of their program. Please understand that what you are doing when completing a jump program is breaking down the muscle.  You aren’t going to see improvements mid-week because the muscle hasn’t healed properly. That’s why I suggest only checking how much you’ve improved at the end of each rest week. Rest is just as important as the routine. 
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Toe Raises – stand with your feet shoulder width apart, typically on stairs or any sort of ground you can stand on that allows your heel to dip down. Then raise up on the tips of your toes. Continue this process until your complete your reps. Don’t rock up and down – or go to fast. For the exercise to work, you have to use correct form and go at a steady pace.


Vertical jump measurements are used primarily in athletic circles to measure performance. The most common sports in which one's vertical jump is measured are track and field, netball, basketball, football, and volleyball, but many sports measure their players' vertical jumping ability during physical examinations. In addition, single and multiple vertical jumps are occasionally used to assess muscular strength and anaerobic power in athletes.[3]
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