The rate of death at 28 days in this study was close to 50%, which is to be expected in a study with very few exclusion criteria and is similar to the rate in previous observational studies.3,9,21-24 Our trial was a pragmatic study that included all patients who were treated for shock states, and therefore, it has high external validity. The study design allowed for maximal exposure to the study drug, since we included patients who had received open-label vasopressors for a maximum of 4 hours before randomization and since during the 28-day study period, the study drug was withdrawn last when patients were weaned from vasopressor therapies and was resumed first if resumption of vasopressor therapy was necessary.

Vertical jump measurements are used primarily in athletic circles to measure performance. The most common sports in which one's vertical jump is measured are track and field, netball, basketball, football, and volleyball, but many sports measure their players' vertical jumping ability during physical examinations. In addition, single and multiple vertical jumps are occasionally used to assess muscular strength and anaerobic power in athletes.[3]