The boundary for stopping the trial owing to the lack of evidence of a difference between treatments at a P value of 0.05 was crossed (Figure 5 in the Supplementary Appendix). There were no significant differences between the groups in the rate of death at 28 days or in the rates of death in the ICU, in the hospital, at 6 months, or at 12 months (Table 2). Kaplan–Meier curves for estimated survival showed no significant differences in the outcome (Figure 2). Cox proportional-hazards analyses that included the APACHE II score, sex, and other relevant variables yielded similar results (Figure 6 in the Supplementary Appendix). There were more days without need for the trial drug and more days without need for open-label vasopressors in the norepinephrine group than in the dopamine group, but there were no significant differences between the groups in the number of days without need for ICU care and in the number of days without need for organ support (Table 3). There were no significant differences in the causes of death between the two groups, although death from refractory shock occurred more frequently in the group of patients treated with dopamine than in the group treated with norepinephrine (P=0.05).
Jonathan Chait escribió en The New Republic que Klein "presta, sorprendentemente (pero, habida cuenta de sus premisas, no es de sorprender), poca atención a las ideas de derecha. Ella reconoce que el neoconservadurismo se encuentra en el corazón del proyecto guerra de Irak, pero no parece saber qué es el neoconservadurismo, y no hace ningún esfuerzo para averiguarlo".16
The dose was determined according to the patient's body weight. Doses of dopamine could be increased or decreased by 2 μg per kilogram per minute and doses of norepinephrine by 0.02 μg per kilogram per minute (or more in emergency cases) (see Figure 1 and Figure 2 in the Supplementary Appendix, available with the full text of this article at NEJM.org). An example of the dose-escalation table is provided in Table 1 in the Supplementary Appendix. The target blood pressure was determined by the doctor in charge for each individual patient. If the patient was still hypotensive after the maximum dose of either agent had been administered (20 μg per kilogram per minute for dopamine or 0.19 μg per kilogram per minute for norepinephrine — doses that have been shown to have similar effects on mean arterial blood pressure12,13), open-label norepinephrine was added. The dose of 20 μg per kilogram per minute for dopamine was selected as the maximal dose because this upper limit was the standard of care in the participating ICUs, in line with expert recommendations14 and international guidelines.15
The record for the most WNBA dunks belongs to Brittney Griner. As a high school senior, she dunked 52 times in 32 games and set a single-game record of seven dunks. As a standout at Baylor University, Griner became the seventh player to dunk during a women's college basketball game and the second woman to dunk twice in a single college game. In her WNBA debut on May 27, 2013, Griner dunked twice, and as of 2014, has five WNBA dunks, including the first in a playoff game (August 25, 2014).
The method described above is the most common and simplest way to measure one's vertical jump, but other more scientifically accurate methods have been devised. A pressure pad can be used to measure the time it takes for an athlete to complete a jump, and then using a kinematics equation (h = g × t2/8), the computer can calculate his or her vertical jump based on the time in the air.